P189 Prospective Validation Study Regarding Disease Complications of the Toronto IBD Global Endoscopic Reporting (TIGER) Score in Ulcerative Colitis and Crohn’s Disease Patients

Abstract Background The recently developed TIGER endoscopy score was established to reliably describe disease severity as it can be utilized for both Ulcerative Colitis (UC) and Crohn’s (CD) patients.1 aim of this study assess the score’s ability predict outcomes regarding complications such surgeries, hospitalizations, drug or disease-related side effects in a sample UC CD patients. Methods A cohort 78 patients with (n=40) (n=38) were included 52-week multiple visit prospective study. Each patient interviews, IBD disk questionnaire, blood draws C-reactive protein (CRP), fecal calprotectin (FC). Endoscopy performed at baseline. Baseline total scores dichotomized <100 (remission-mild activity) ≥100 (moderate-severe predictor effects. Results At baseline, compared <100, had significantly higher CRP, FC, disk. In patients, terms 52-weeks, baseline increased likelihood being hospitalized (p<0.02). More specifically, 38.5% 34.5% experienced least one hospitalization, respectively. Comparatively, there zero hospitalizations <100. 0% 11.1% surgery 3.9% 24.1% ≥100, effects, reporting effect from medications (p<0.006). reported medication 11.5% 19.2% Conclusion endoscopic demonstrates significant association FC Moreover, measure moderate-to-severe burden experiencing complications. 1. Zittan E, et al. J Crohns 2022;16:544-553.